die f\u00fcr den Ausbruch verantwortlich sind: <\/p>\n
Und damit w\u00e4chst die Hoffnung auf ein Gegenmittel!<\/p>\n
Quelle BBC-NEWS von heute:
Page last updated at 00:00 GMT, Sunday, 27 December 2009<\/p>\n
\nStudy blames two genes for aggressive brain cancer<\/p>\n
\nBrain section<\/p>\n
\nGlioblastoma is a deadly form of brain cancer<\/p>\n
Scientists have discovered two genes that appear responsible for one of the most aggressive forms of brain cancer.<\/p>\n
Glioblastoma multiforme rapidly invades the normal brain, producing inoperable tumours, but scientists have not understood why it is so aggressive.<\/p>\n
The latest study, by a Columbia University team, published in Nature, pinpoints two genes.<\/p>\n
The researchers say that the findings raise hopes of developing a treatment for the cancer.<\/p>\n
\nIt means we are no longer wasting time developing drugs against minor actors in brain cancer – we can now attack the major players<\/p>\n
\nDr Antonio Iavarone<\/p>\n
\nColumbia University<\/p>\n
The genes – C\/EPB and Stat3 – are active in about 60% of glioblastoma patients.<\/p>\n
They appear to work in tandem to turn on many other genes that make brain cells cancerous.<\/p>\n
Patients in the study whose tumours showed evidence of both genes being active died within 140 weeks of diagnosis.<\/p>\n
In contrast, half of patients without activity from these genes were alive after that time.<\/p>\n
Master controls<\/p>\n
Lead researcher Dr Antonio Iavarone described the two genes as the disease’s master control knobs.<\/p>\n
He said: „When simultaneously activated, they work together to turn on hundreds of other genes that transform brain cells into highly aggressive, migratory cells.<\/p>\n
„The finding means that suppressing both genes simultaneously, using a combination of drugs, may be a powerful therapeutic approach for these patients, for whom no satisfactory treatment exists.“<\/p>\n
When the researchers silenced both genes in human glioblastoma cells, it completely blocked their ability to form tumours when injected in a mouse.<\/p>\n
The Columbia team is now attempting to develop drugs they hope will achieve the same effect.<\/p>\n
Using state-of-the-art techniques, they effectively mapped out the comprehensive and highly complex network of molecular interactions driving the behaviour of glioblastoma cells.<\/p>\n
Dr Iavarone said: „The identification of C\/EPB and Stat3 came as a complete surprise to us, since these genes had never been implicated before in brain cancer<\/p>\n
„From a therapeutic perspective, it means we are no longer wasting time developing drugs against minor actors in brain cancer – we can now attack the major players.“<\/p>\n
Nell Barrie, science information officer at Cancer Research UK, said: „This research is exciting, as it sheds light on the key changes that drive cells in the brain to become glioblastoma cells.<\/p>\n
„By finding out exactly how healthy cells turn into cancer cells, scientists hope to find clues for preventing or reversing the process.<\/p>\n
„The technique used in this study should help scientists to understand these changes in other types of cancer, leading to new and more personalised treatment approaches in the future.“<\/p>\n
SEE ALSO<\/p>\n
\nHope for new brain tumour vaccine<\/p>\n
\n30 Apr 06 | Health<\/p>\n
\nGene clue to brain tumour growth<\/p>\n
\n23 Nov 09 | Health<\/p>\n
\nGenetic clue to brain cancer risk<\/p>\n
\n05 Jul 09 | Health<\/p>\n
\nBrain tumours ‚forgotten cancer‘<\/p>\n
\n02 Jul 09 | Health<\/p>\n
RELATED BBC LINKS<\/p>\n
\nBrain cancer<\/p>\n
RELATED INTERNET LINKS<\/p>\n
\nColumbia University<\/p>\n
\nCancer Research UK<\/p>\n
\nThe BBC is not responsible for the content of external internet sites<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
die f\u00fcr den Ausbruch verantwortlich sind: <\/p>\n
Und damit w\u00e4chst die Hoffnung auf ein Gegenmittel!<\/p>\n
Quelle BBC-NEWS von heute:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-86029","post","type-post","status-publish","format-standard","hentry","category-femgesundheit","entry"],"yoast_head":"\n